Apple polyphenols extract

Apple polyphenols extract has a positive effect on vascular oxidative stress and endothelium function. Abstract Author(s): Arrigo F G Cicero, Cristiana Caliceti, Federica Fogacci, Marina Giovannini, Donato Calabria, Alessandro Colletti, Maddalena Veronesi, Aldo Roda, Claudio Borghi Abstract: SCOPE: We aimed examining apple polyphenols' effect on uricemia and endothelial function in a sample of overweight subjects. METHODS AND RESULTS: This was a two-phases study. In vitro experiment aimed to evaluate apple polyphenols' ability to lower uric acid in comparison with allopurinol. In vivo study consisted in a randomized, double-blind, parallel placebo-controlled clinical trial involving 62 overweight volunteers with suboptimal values of fasting plasma glucose (100mg/dL=FPG=125mg/dL), randomized to 300mg apple polyphenols or placebo for 8 weeks. Apple polyphenols extract inhibited xanthine oxidase activity, with an IC50 = 130±30 ng/mL; reducing uric acid production with an IC50 = 154±28 ng/mL. During the trial, after the first 4 weeks of treatment, FPG decreased in the active treated group (-6,1%,P<0,05), while no significant changes were observed regarding the other hematochemistry parameters. After 4 more weeks of treatment, active-treated patients had an improvement in FPG compared to baseline (-10,3%,P<0,001) and the placebo group (P<0,001). Uric acid (-14,0%,P<0,05 vs baseline; P<0,05 vs placebo) and endothelial reactivity (0,24±0,09,P = 0,009 vs baseline; P<0,05 vs placebo) significantly improved too. CONCLUSION: In vivo, apple polyphenols extract has a positive effect on vascular oxidative stress and endothelium function and reduce FPG and uric acid by inhibiting xanthine oxidase, as our in vitro experiment attests. This article is protected by copyright. All rights reserved. Article Published Date : Jul 28, 2017 Study Type : Human Study Additional Links Substances : Apple Polyphenols : CK(52) : AC(25) Diseases : Endothelial Dysfunction : CK(1210) : AC(237), Hyperuricemia : CK(227) : AC(49), Overweight : CK(3643) : AC(612) Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hypoglycemic Agents : CK(1446) : AC(342), Uricosuric Agents : CK(2) : AC(1) Abstract Source: Mol Nutr Food Res. 2017 Jul 29. Epub 2017 Jul 29. PMID: 28755406


Lutein, the super compound

Estructura en 3D de la molécula de luteína, presente en vegetales y frutas. Pigmento amarillo característico.


Daily consumption of tea may protect the elderly from cognitive decline

The importance of this finding leds me to publish it as it comes.

Daily consumption of tea may protect the elderly from cognitive decline, study suggests
March 16, 2017
National University of Singapore
Tea drinking reduces the risk of cognitive impairment in older persons by 50 per cent and as much as 86 per cent for those who are genetically at risk of Alzheimer's, new research suggests.

NUS researchers found that regular consumption of tea brewed from tea leaves reduces elderly persons' risk of cognitive decline.
Credit: © Serhiy Shullye / Fotolia
A cup of tea a day can keep dementia away, and this is especially so for those who are genetically predisposed to the debilitating disease, according to a recent study led by Assistant Professor Feng Lei from the Department of Psychological Medicine at National University of Singapore's (NUS) Yong Loo Lin School of Medicine.

The longitudinal study involving 957 Chinese seniors aged 55 years or older has found that regular consumption of tea lowers the risk of cognitive decline in the elderly by 50 per cent, while APOE e4 gene carriers who are genetically at risk of developing Alzheimer's disease may experience a reduction in cognitive impairment risk by as much as 86 per cent.

The research team also discovered that the neuroprotective role of tea consumption on cognitive function is not limited to a particular type of tea -- so long as the tea is brewed from tea leaves, such as green, black or oolong tea.

"While the study was conducted on Chinese elderly, the results could apply to other races as well. Our findings have important implications for dementia prevention. Despite high quality drug trials, effective pharmacological therapy for neurocognitive disorders such as dementia remains elusive and current prevention strategies are far from satisfactory. Tea is one of the most widely consumed beverages in the world. The data from our study suggests that a simple and inexpensive lifestyle measure such as daily tea drinking can reduce a person's risk of developing neurocognitive disorders in late life," explained Asst Prof Feng.

He added, "Based on current knowledge, this long term benefit of tea consumption is due to the bioactive compounds in tea leaves, such as catechins, theaflavins, thearubigins and L-theanine. These compounds exhibit anti-inflammatory and antioxidant potential and other bioactive properties that may protect the brain from vascular damage and neurodegeneration. Our understanding of the detailed biological mechanisms is still very limited so we do need more research to find out definitive answers."

In this study, tea consumption information were collected from the participants, who are community-living elderly, from 2003 to 2005. At regular intervals of two years, these seniors were assessed on their cognitive function using standardised tools until 2010. Information on lifestyles, medical conditions, physical and social activities were also collected. Those potential confounding factors were carefully controlled in statistical models to ensure the robustness of the findings.

The research team published their findings in scientific journal The Journal of Nutrition, Health & Aging in December 2016.

Future Research

Asst Prof Feng and his team are planning to embark on further studies to better understand the impact of Asian diet on cognitive health in aging. They are also keen to investigate the effects of the bioactive compounds in tea and test them more rigorously through the assessment of their biological markers and by conducting randomised controlled trials or studies that assign participants into experimental groups or control groups randomly to eliminate biased results.

Story Source:

Materials provided by National University of Singapore. Note: Content may be edited for style and length.

Journal Reference:

L. Feng, M. -S. Chong, W. -S. Lim, Q. Gao, M. S. Z. Nyunt, T. -S. Lee, S. L. Collinson, T. Tsoi, E. -H. Kua, T. -P. Ng. Tea consumption reduces the incidence of neurocognitive disorders: Findings from the Singapore longitudinal aging study. The Journal of Nutrition, Health & Aging, 2016; 20 (10): 1002 DOI: 10.1007/s12603-016-0687-0
Cite This Page:

National University of Singapore. "Daily consumption of tea may protect the elderly from cognitive decline, study suggests." ScienceDaily. ScienceDaily, 16 March 2017. <www.sciencedaily.com/releases/2017/03/170316093412.htm>.

Imagen de Internet. El té verde lo tomo con el mate


A complex mix of plant compounds derived from Traditional Chinese Medicine works to kill cancer cells.

Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China -- a Traditional Chinese Medicine -- works to kill cancer cells.
Compound kushen injection (CKI) is approved for use in China to treat various cancer tumours, usually as an adjunct to western chemotherapy -- but how it works has not been known.
This study, published in the journal Oncotarget, is one of the first to characterise the molecular action of a Traditional Chinese Medicine rather than breaking it down to its constituent parts.
"Most Traditional Chinese Medicine are based on hundreds or thousands of years of experience with their use in China," says study leader, Professor David Adelson, Director of the Zhendong Australia -- China Centre for the Molecular Basis of Traditional Chinese Medicine.
"There is often plenty of evidence that these medicines have a therapeutic benefit, but there isn't the understanding of how or why.
"If we broke down and tested the components of many Traditional Chinese Medicines, we would find that individual compounds don't have much activity on their own. It's the combination of compounds which can be effective, and potentially means few side-effects as well.
"This is one of the first studies to show the molecular mode of action of a complex mixture of plant-based compounds -- in this case extracts from the roots of two medicinal herbs, Kushen and Baituling -- by applying what's known as a systems biology approach. This is a way of analysing complex biological systems that attempts to take into account all measurable aspects of the system rather than focussing on a single variable."
The Zhendong Australia China Centre for Molecular Traditional Chinese Medicine was established at the University of Adelaide in 2012 in a collaboration with the China-based Shanxi College of Traditional Chinese Medicine and Zhendong Pharmaceutical Company.
The Centre was established with a donation by the Zhendong Pharmaceutical Company, with the aim of understanding how Traditional Chinese Medicine works, and the long-term aim of possible integration into western medicine.
The researchers used high-throughput next generation sequencing technologies to identify genes and biological pathways targeted by CKI when applied to breast cancer cells grown in the laboratory.
"We showed that the patterns of gene expression triggered by CKI affect the same pathways as western chemotherapy but by acting on different genes in the same pathways," says Professor Adelson.
"These genes regulate the cell cycle of division and death, and it seems that CKI alters the way the cell cycle is regulated to push cancer cells down the cell death pathway, therefore killing the cells."
Professor Adelson says this technique could be used to analyse the molecular mechanisms of other Traditional Chinese Medicines, potentially opening their way for use in western medicine.

University of Adelaide. "How Chinese medicine kills cancer cells." ScienceDaily. ScienceDaily, 8 September 2016. <www.sciencedaily.com/releases/2016/09/160908084319.htm>.


Chronic kidney disease and some anti-acids

According to data released by the American Society of Nephrology (ASN). ("Acid reflux medications kidney disease May Increase Risk." ScienceDaily. ScienceDaily, 27 October 2015) the over use of anti-acids proton-pump inhibitors type (omeprazole, lansoprazole, etc.), may contribute in some cases , to the emergence or worsening of chronic kidney disease.

This is a warning about the misuse of these drugs, which, although they are useful in controlling the the reflux acidity, should be used under strict medical supervision.

Efforts to limit its use must be continuous, since in many cases, heartburn and reflux can be controlled or reduced by other measures, behavior, diet, exercise, use of other medications, etc.

There is a warning from the medical community, since more than half of patients who use these drugs, do not need them.